Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system
نویسندگان
چکیده
منابع مشابه
Fibroblast Growth Factor 8 Deficiency Compromises the Functional Response of the Serotonergic System to Stress
Functionally heterogeneous populations of serotonergic neurons, located within the dorsal raphe nucleus (DR), play a role in stress-related behaviors and neuropsychiatric illnesses such as anxiety and depression. Abnormal development of these neurons may permanently alter their structure and connections, making the organism more susceptible to anxiety-related disorders. A factor that critically...
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In this review, we propose a broader view of the role of the fibroblast growth factor (FGF) family in modulating brain function. We suggest that some of the FGF ligands together with the FGF receptors are altered in individuals with affective disorder and modulate emotionality in animal models. Thus, we propose that members of the FGF family may be genetic predisposing factors for anxiety, depr...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2014
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2014.01.053